R&D

Process R&D development… our main strength!


 

In Farmhispania we know that "on time" market arrival is nowadays the most critical factor to guarantee successful business, that is why our technical staff scale up efficiently delivering validated R&D material for NDAs and ANDAs "on time".

We are specialised in tailor-made research and process development of advanced pharmaceutical intermidiates and APIs. Processes based on complex chemical reactions take place on daily basis. Our chemistry knowledge goes from Friedel Crafts, Beckman rearrangements, titanium chemistry (Mc. Murry reaction), palladium chemistry (Heck, Sonogashira coupling), through homogeneous and heterogeneous large scale pressure hydrogenations, NCA couplings, Hydrogen Transfer Catalysis (HTC), Phase Transfer Catalysis (PTC), methylations, peptide chemistry, phosphorous chemistry, heterocyclic chemistry, steroid chemistry, esterifications, hydrolisis, epimerizations to oxidations and reductions.

 

Our 30 qualified chemists in our process and analytical R&D team perform process and analytical
 R&D in our modern facilities equipped with state-of-the-art instrumentation, including: GC, HPLC, HPLC-MS, preparative HPLC, UV, IR, DSC, Malvern (laser diffraction for PSD determination).

Working from gram-scale to KGs in the new cGMP pilot plants.

We are experienced in the development and manufacture of independent and patentable processes and polymorphic forms of APIs.

   
Process Research
Synthesis Design
Synthesis and characterization of impurities
Fully equipped laboratories

Process Development
State-of-the-art Pilot Plant facilities
Process validation
Fully cGMP compliance

   
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